新葡萄(8883·AMG)官方网站-Grand Lisboa Macau

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We are interested in developing and applying novel s pectroscopic reporters, methods, and techniques to study the structure-dynamics-function (or reactivity) relationship of various chemical and biological systems, such as peptides and proteins, with a focus on assessing the kinetic and mechanistic details of the chemical/biological processes and/or reactions in question. Our current research efforts include, but are not limited to, (1) development of unnatural amino acid-based, environmentally-sensitive vibrational probes for site-specific interrogation of protein structure, hydration, electrostatics, dynamics, and function，(2) development of unnatural amino acid-based fluorescence reporters for biological spectroscopy and microscopy，(3)development of unnatural amino acid-based fluorescence resonance energy transfer (FRET) or photoinduced electron transfer (PET) pairs for characterization of protein conformations, conformational change, and conformational dynamics, (4) development of biological materials, such as fibrils, that have tailored spectroscopic or optical properties, (5) assessment of the kinetics and mechanism of protein folding under in vitro and in vivo conditions, (6) site-specific interrogation of the molecular interactions between protein sidechains and naturally-occurring osmolytes as well as ions. (7) manipulation of biological electron and proton transfer processes via site-selective tuning of the underlying driving force, (8) development of multidimensional spectroscopic and imaging techniques for chemical, biological, and physical applications.

新葡萄88833官网AMG